Optimal Development of Mature B Cells Requires Recognition of Endogenous Antigens
نویسندگان
چکیده
منابع مشابه
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Survival of human lymphoma cells requires B-cell receptor engagement by self-antigens.
The activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL) relies on chronic active B-cell receptor (BCR) signaling. BCR pathway inhibitors induce remissions in a subset of ABC DLBCL patients. BCR microclusters on the surface of ABC cells resemble those generated following antigen engagement of normal B cells. We speculated that binding of lymphoma BCRs to self-antigens in...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2019
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.1900175